What is a significant risk factor for developing septic shock?

Infection is a significant risk factor for developing septic shock because septic shock arises as a severe complication of sepsis. Sepsis itself is the body's extreme response to an infection, where the immune system releases chemicals into the bloodstream to fight the infection, which can lead to widespread inflammation, blood clots, and leaky blood vessels. This can ultimately culminate in a dangerous drop in blood pressure, organ failure, and can be life-threatening if not addressed promptly.

While low blood pressure, dehydration, and trauma can contribute to a patient's overall condition or complicate their health situation, they are not direct causes of septic shock like infection is. The primary mechanism leading to the life-threatening state of septic shock stems from the body's response to an infection, making it the most significant risk factor in this context.